Games like Space Run

SENTRY is an action-defense first person shooter where you defend your spaceship against invading aliens. Plot an escape route through hostile space and battle the enemy across your vessel with the support of traps, turrets and environmental destruction.

Defend humanity's last hope, pilot a powerful mech, in Frontlines Crisis! A battlefield swarming with insects makes strategic and combat decisions crucial. Each decision will determine your fate. Defend humanity's last sanctuary, fight fiercely, and uphold human honor with wits and courage!

Stellar Initiative is a roguelike tower defense game where you land on the planet and use your orbit ship to deliver buildings and support you with fire. Complete missions, install new upgrades, discover powerful artifacts, and find the best strategy!

The Last Starship is a 2D space construction game where you design and upgrade your starship. Choose your path: pirate hunter, miner, engineer, spacebus driver, and more, whilst exploring vibrant star systems. Enjoy a growing sandbox world, with regular free updates. Your cosmic adventure awaits!

The RTS/FPS phenomenon has moved into space! Build your base on an asteroid, command fleets of starships for epic battles, pilot fighters, mine and trade resources, assemble robots to defend or assault other stations. Take sole command or share the glory as you fight for control of the quadrant.

Build and design the terrain while defending your stronghold against alien invasion in this unique Roguelike tower defense. Choose from 30 heroes, survive enemy waves, and upgrade a variety of destructive towers to hold the line!

Create a thriving space station in a lost sector. Face thrilling challenges head-on, from pirate raids to asteroid impacts, as you lead your company to new heights.

Lead a squadron against the Drone invasion in a top-down space shooter with RPG depth. Take contracts across three galaxies, outfit and upgrade your ship, recruit wingmen, and push the story through to the Nexus.

Jump Space (formerly Jump Ship) is a mission based co-op PvE for 1-4 players, where you are the crew of a spaceship. Transition seamlessly from crewing the ship to on-foot exploration and space walks. Explore, upgrade, and survive intense encounters in deep space together.

Build twisting mazes with tetromino blocks and deploy unique towers in this strategic roguelite tower defense adventure!

Hexguardian is a roguelite, tower defense game where you build your own maps with hexagonal tiles! Build and upgrade towers, recruit armies, learn spells, construct wonders and place hexagonal tiles to create a path to enhance your defenses. With plenty of game modes and talents to unlock!

Starcom: Unknown Space is an action RPG of space exploration and adventure. Build your own starship while discovering an epic story in a universe of strange mysteries, alien factions and uncharted worlds.

A defense RTS where you can move turrets at will. Extract resources, upgrade technology, and defend against enemy swarms in a gripping space campaign. Hold the line, set up your turrets, and brace for screen-filling hordes!

From Glory To Goo is a Sci-Fi survival RTS set on an alien world. Serve as humanity's bulwark by establishing a colony and supporting your colonists still in orbit. But beware, for The Goo, a relentless and shape-shifting force approaches from all sides, even above and below.

Become the Captain of an interstellar cruiser and journey across the galaxy to save the Republic. During your journey you will have to make important decisions, improve the weaponry of your ship and fight against numerous enemies.

Axon TD lets you expand the map boundaries themselves. A huge arsenal of towers and a wide variety of enemies clash in a battlefield that grows to your whims. Engage in single, cooperative, and roguelite gameplay.

Command Mobile Outpost and take XEN Firearm to venture deep into the Signet surveillance off-limit area. Collect unique Weapon Units. Amp up the firepower of the Outpost that fights with you. This is an FTD game - FPS, Tower Defense, Base Building and much more all at the same time.

Command an ancient starship and fight your way to the heart of a dying Empire. Fend off attacks from demented cultists, craven space pirates, and xenophobic Imperial soldiers. Discover powerful artifacts and use them to build your ship into a fearsome war engine.

Deep Space Cache is a short & simple semi-idle bullet heaven incremental asteroid miner game.

Artisan TD is a puzzle-oriented Tower Defense game where you must survive by building mazes.

Collect resources and establish a defense line before dark And then Facing countless enemies

Cluckmech Oasis, a top-down shooting Roguelike tower defense game. Play as the Warcluck and lead your team of animal heroes in a fight for survival. Collect, build and upgrade defenses, and engage in intense battle against waves of plant enemies.

The unstoppable alien force known as The Creeper has returned, devouring thousands of worlds in its path, and yours is next. Battle against the Creeper fluid in a groundbreaking pixel-level simulation to prove that humanity will rule the galaxy forever!

Battle for galactic dominance in this real-time 4X strategy game with unrivaled scale! You’ll explore, expand, exploit, and exterminate through military force, diplomacy, trade, culture, influence, and other underhanded tactics.

Starship Theory is a ship building survival game. Mine and trade to gather resources. Plan and construct new upgrades. Train and manage crew. Fight to survive.

Embark on a space voyage with your ragtag crew of civilians in search of a new home. Build spaceships tile by tile, create optimal gas conditions, manage the needs and moods of their crew, encounter other space-faring groups, and explore the universe in this spaceship colony simulation.

You are the Kingdom’s Commander. Choose new contracts strategically. Use towers but save your gold. Use 12 powerful God/saint spells. Finish Contracts quickly. Stack gold and reputation rapidly. Choose and upgrade 36 perks blessed by 12 Gods/saints. Become the Legend of the Kingdoms.

Tactical, beautiful, and wholly unique, the GOTY-winning sci-fi RTS returns with Homeworld 3. Assume control and battle through fleet combat in dazzling, fully 3D space while the award-winning story unfolds on a galactic scale.

"Void Breaker" – An incredibly addictive tower defense shooting game!

You are deployed to the desolate red planet to reforge humanity's hope. With no hospitable atmosphere, no nurturing water sources, only relentless storms, unknown alien creatures, you must use wit and determination to survive on this alien land and build a Mars base of your own.

This is a idle game modeled on industrial building gameplay. It will be three-dimensional, complex industrial assembly line, easy, simple plane conveyor belt. At the same time to join the battleship assembly, space campaign, character development, giant construction, trade orders and other gameplay!

Are you prepared for a thrilling toy army tower defense adventure? Welcome to the Toy Shire! Battle diverse foes in various locations, defend your family, and repel foes from your area. Save the world by strengthening your defense with toy towers!

Experience the first-ever open world Star Wars™ game and explore distinct locations across the galaxy, both iconic and new. Risk it all as scoundrel Kay Vess, seeking freedom and the means to start a new life.

Space Engineers 2 is a playable Early Access Alpha sandbox focused on engineering, exploration, and colonization in a fully destructible universe. Design and build ships, stations, and planetary bases while uncovering the story of Miro and Ivan Sokol. Help shape the future of the Almagest system.

Mineral Defense combines tower defense with roguelite elements and procedural generation. Build paths, unlock upgrades, and unleash powerful synergies to conquer evolving challenges in an ever-expanding world.

Take command of a civilization that has just achieved faster-than-light travel in Galactic Civilizations IV, the newest entry in the award-winning space 4X strategy game series. Explore the galaxy, colonize worlds, shape cultures, make alliances, fight wars and pioneer new technologies.

Tower Factory is a tower defense and automation game with roguelite elements. Optimize resource production using conveyor systems while defending against monster waves. Can you find and destroy the enemy tower before it's too late?

Sid Meier's Alpha Centauri™ Planetary Pack includes the original Alpha Centauri and the expansion, Alien Crossfire.

Corporate greed meets strategic planet-mining in Drill Core! Drill to the heart of planets while managing workers, researching cutting-edge tech, and fortifying against alien attacks. Will you prioritize efficiency and risk your workers' safety, or focus on defense for survival?

Blast your way through waves of space debris in order to reach what is waiting for you on the other side. Find your fighting style with multiple unlockable ships in this fast paced space adventure!

The spiritual successor to Freelancer with a Lovecraftian, sandbox RPG twist. Explore a vast handmade universe with mod support and PvP/co-op multiplayer. You're going to need a bigger ship.

Star Survivor is a space-themed survival game that blends intense deckbuilding strategy. Pilot humanity's last spaceship through the vast galaxy, Unlock powerful weapon combos, collect card modules, and craft unique builds. As the enemy swarms grow denser, will you be the last one standing?

Welcome to the asteroid belt. The work is dangerous, the asteroids are temporary, and Earth is prohibitively expensive. Build automated mining operations, complete contracts, and earn your way back home.

Astrometica is a space exploration and base-building survival game. After a catastrophic event, explore vast space, gather resources, build bases, and uncover cosmic mysteries. Use advanced technology, craft tools, and discover new blueprints to survive and thrive in the unknown.

Topple Tactics is a physics-based multiplayer tower defense game where one huge player controls the map by placing towers and using abilities, whilst the little players level up their stats and equipment to reach the end of the map and defeat the huge player!

Mine by day, defend by night. Master 25+ spells, sell rare ores for gear upgrades, and grow stronger each run in this procedurally generated roguelite tower defense. Enjoy full controller and Steam Deck support.

Land on unique planets to survive the horrors that await in this adventure survival RPG. Use the spoils to upgrade defensive buildings and explore the galaxy further. Can you survive the hunt all alone?

Explore endless Universe and create the most efficient constellation of colonies. Build conveyor systems to automate production. Take care of Astronauts and their needs! Establish new colonies as part of intergalactic simulation.

Takara Cards is a unique tactical deck-builder RPG about chasing space dragons in a sci-fi fantasy universe. Create your deck as you explore sectors, fighting your way in deep puzzly combat. Every decision you make affects your Ship and Character: Each new adventure offers new surprises!

Haul cargo, trade salvage and keep your space suit close as you search for fame and fortune among the stars in a game that puts an interstellar twist on the truck sim genre.

From commanding the battle standing on the bridge of your flagship all the way down to tactical infantry firefights - AFF brings together all the combat you ever loved in a rich science fiction setting. Boarding, pilotable capital ships, deep weapon customization and full Bot support included!

A co-op horror about scavenging at abandoned moons to sell scrap to the Company.

Unleash the power of specialized towers to annihilate hordes of monsters in this idle game with roguelike elements. Collect gold, level up your towers, face powerful bosses, and refine your strategy with an evolving skill tree.

'The Pair Annihilation' is grid + turn-based strategy roguelike game. Use different combinations of ships, different artifacts, in battles on various battlefields to defeat Udtmos!