Games like Defend Your Life: TD
by Alda Games
Defend Your Life! Is tower defense set in human body where players are fighting against villain hordes of viruses and bacteria. Levels and units correspond to reality of human anatomy.
View on Steam · $9.99 →
Ranked by how similar the games actually are, not by sales. Released and Price are remembered for next time.
Closest matches
-90%$1.19Hexguardian
May 2 · Split Second Games
Both: Tower Defense · Cartoony · RTS
Hexguardian is a roguelite, tower defense game where you build your own maps with hexagonal tiles! Build and upgrade towers, recruit armies, learn spells, construct wonders and place hexagonal tiles to create a path to enhance your defenses. With plenty of game modes and talents to unlock!
Tower DefenseCartoonyRogueliteRoguelikeStrategyHex GridProcedural GenerationTacticalRTS3D👍 617
$19.99Kingdom Rush 5: Alliance TD
Jul 25 · Ironhide Game Studio
Both: Tower Defense · Cartoony · Funny
While a formidable evil emerges, an unexpected alliance is taking shape! It will take the finest warriors of Linirea and the relentless Dark Army to stop it. Beware! Though they may journey side by side the ever-changing winds of fate could swiftly alter their course.
StrategyTower Defense2DSingleplayerCartoonCartoonyFantasyDragonsBuildingFunny👍 10,367
-40%$10.49Tower Dominion
May 7 · Parallel 45 Games
Both: Tower Defense · RTS
Build and design the terrain while defending your stronghold against alien invasion in this unique Roguelike tower defense. Choose from 30 heroes, survive enemy waves, and upgrade a variety of destructive towers to hold the line!
Tower DefenseStrategyBase BuildingRoguelikeRTSTacticalRogueliteChoices MatterProcedural GenerationResource Management👍 5,124
$9.99Toy Shire
Aug 26 · Bluespy Studios
Both: Tower Defense · RTS
Are you prepared for a thrilling toy army tower defense adventure? Welcome to the Toy Shire! Battle diverse foes in various locations, defend your family, and repel foes from your area. Save the world by strengthening your defense with toy towers!
Early AccessTower DefenseStrategyRTSCuteWholesomeFamily FriendlyReal Time TacticsActionMilitary👍 702
$4.99clickyland
Jun 3 · Sokpop Collective
Both: Tower Defense · RTS
clickyland is a tower defense village builder where clicks are your main resource. Use clicks to harvest resources, fight enemies and manage your village, but use them wisely as you only get 20 clicks every day! Can you reach day 100?
StrategyTower DefenseBase BuildingCity Builder3DSingleplayerRTSSurvivalMedieval👍 622
$5.99Frontline Crisis
Aug 14 · BCQT
Both: Tower Defense · RTS
Defend humanity's last hope, pilot a powerful mech, in Frontlines Crisis! A battlefield swarming with insects makes strategic and combat decisions crucial. Each decision will determine your fate. Defend humanity's last sanctuary, fight fiercely, and uphold human honor with wits and courage!
Tower DefenseTop-Down ShooterRTSStrategyPixel GraphicsSpaceMechsLocal Co-OpAction RTS1980s👍 348
$7.99Northend Tower Defense
Sep 4 · Northend Games
Both: Tower Defense
Jump into a realtime strategy, action filled battlefield, deploy relentless soldiers, unlock powerful troops and vehicles, upgrade your army, decimate the enemy. If that's not enough, jump into a chaotic Zombie mode, with traps, fun upgrades, and a new gameplay!
Tower DefenseIndieStrategyAuto BattlerWarAction RTSReal Time TacticsManagementTacticalMilitary👍 1,308
$14.99Tower Factory
Nov 7 · Gius Caminiti
Both: Tower Defense · RTS
Tower Factory is a tower defense and automation game with roguelite elements. Optimize resource production using conveyor systems while defending against monster waves. Can you find and destroy the enemy tower before it's too late?
AutomationTower DefenseStrategyRTSRogueliteRoguelikeBase BuildingResource ManagementManagementCrafting👍 1,221
$9.99Cluckmech Oasis
May 9 · BlackLight
Both: Tower Defense
Cluckmech Oasis, a top-down shooting Roguelike tower defense game. Play as the Warcluck and lead your team of animal heroes in a fight for survival. Collect, build and upgrade defenses, and engage in intense battle against waves of plant enemies.
StrategyRoguelikeTower DefensePixel GraphicsTop-Down ShooterCuteRogueliteBuildingActionShooter👍 3,078
$14.99IDUN - Frontline Survival
Jan 20 · IDUN Interactive
Both: Tower Defense · RTS
A defense RTS where you can move turrets at will. Extract resources, upgrade technology, and defend against enemy swarms in a gripping space campaign. Hold the line, set up your turrets, and brace for screen-filling hordes!
3DBuildingWargameTower DefenseStrategyRTSSurvivalBase BuildingMiningSci-fi👍 685
$19.99Axon TD: Uprising - Tower Defense
Sep 27 · Element Studios
Both: Tower Defense · RTS
Axon TD lets you expand the map boundaries themselves. A huge arsenal of towers and a wide variety of enemies clash in a battlefield that grows to your whims. Engage in single, cooperative, and roguelite gameplay.
Tower DefenseReal Time TacticsRogueliteStrategyPvERTSRoguelikeOnline Co-OpSci-fiTactical👍 707
-50%$13.99Age of Darkness: Final Stand
Jan 15 · PlaySide
Both: Tower Defense · RTS
Age of Darkness: Final Stand is a dark fantasy survival RTS where you must illuminate, build and defend humanity’s last bastion against hordes of Nightmares. Set in the remnants of a kingdom consumed by a deadly fog, you decide. Will you hide in the light? Or take back your world.
Tower DefenseAction RTSRTSStrategyBase BuildingPvEDark Fantasy3DFantasyStylized👍 9,487
$9.99Topple Tactics
Oct 20 · Braian Strak
Both: Tower Defense · Funny
Topple Tactics is a physics-based multiplayer tower defense game where one huge player controls the map by placing towers and using abilities, whilst the little players level up their stats and equipment to reach the end of the map and defeat the huge player!
PhysicsComedyColorfulTower DefenseMultiplayerCasualPvPStrategyFunnyAction👍 1,369
-30%$8.39From Glory To Goo
Apr 2 · Stratagem Blue
Both: RTS · Tower Defense
From Glory To Goo is a Sci-Fi survival RTS set on an alien world. Serve as humanity's bulwark by establishing a colony and supporting your colonists still in orbit. But beware, for The Goo, a relentless and shape-shifting force approaches from all sides, even above and below.
Base BuildingRTSTower DefenseReal-Time with PauseAction RTSResource ManagementColony SimCity BuilderStrategySandbox👍 1,796
-70%$2.39Necrosmith 2
Mar 27 · Alawar
Both: Tower Defense
Like a dead man reanimated by dark sorcery, the necromancer simulator is back! Give the undead the ability to fly over mountains and swim across rivers, explore a fully generated world at night and fend off enemy hordes during the day. Start a new, uhm, life.
Tower DefenseStrategyRogueliteReal-TimeBullet HellManagementSimulationTop-DownActionExploration👍 1,316
$7.99HoloParade
Nov 30 · Roboqlo
Both: Tower Defense
Collect your favorite characters, nurture them, and have fun just watching in this hololive fan game! It's a 2D tower defense game that offers depth for dedicated players, strategic elements, and easy enjoyment for casual players.
StrategyTower DefenseSide ScrollerReal Time Tactics2DCuteTacticalIndieSingleplayerHand-drawn👍 1,132
$14.99Mineral Defense
Nov 15 · Corestone Games
Both: Tower Defense
Mineral Defense combines tower defense with roguelite elements and procedural generation. Build paths, unlock upgrades, and unleash powerful synergies to conquer evolving challenges in an ever-expanding world.
StrategyRogueliteTower DefenseCard GameRoguelike3DBase BuildingCasualDeckbuildingProcedural Generation👍 220
$19.99Nordhold
Mar 25 · StunForge
Both: Tower Defense
Enemies are coming! Every decision matters: build your city, grow the economy, and prepare for enemy waves. Strengthen your defenses, adapt your strategy, and unleash your hero’s full potential. This unique Tower Defense will test your skills – are you worthy to claim a place at Valhalla?
Tower DefenseStrategyRogueliteDark FantasyTurn-Based StrategyRoguelikeIndieBase BuildingCity BuilderManagement👍 2,876
$4.99Operation: Outbreak Idle
Sep 4 · DeadLogics
Both: Tower Defense
Command automated military defenses, upgrade your fortress, and survive massive zombie waves in this action-packed idle defense game. Build powerful defenses, unlock upgrades, and hold the line against endless undead hordes.
Tower DefenseZombiesStrategySingleplayerCasualSurvivalShoot 'Em UpIncrementalShooter3D
Also worth a look
Share some of the same DNA, but further from the original.
$23.99ShapeHero Factory
Sep 17 · Asobism.Co.,Ltd
Both: Tower Defense
In ShapeHero Factory, you’re the engineer of an ever-evolving paint-fuelled factory that spits out magical, shape-based warriors. Send them into battle - to death or glory - then build an even better factory on your next run.
AutomationBase BuildingTower DefenseRogueliteResource Management2.5DCuteStrategyBuildingSimulation👍 991
$8.99Skel Dungeon: Heroes Must Die!
Oct 21 · Buff Studio
Both: RTS · Tower Defense
Skel Dungeon is a real-time strategy defense game. Become a small skeleton and defeat the heroes invading your dungeon. Set up and upgrade trap rooms, expand your dungeon, and strengthen your skeleton to stand against increasingly powerful heroes.
MedievalHack and SlashRTSTower DefenseActionAction RTSDark FantasyStrategyFantasyBase Building
$4.99Kingdom Contracts Tower Defense Incremental
Aug 14 · Day 1 to 100
Both: Tower Defense
You are the Kingdom’s Commander. Choose new contracts strategically. Use towers but save your gold. Use 12 powerful God/saint spells. Finish Contracts quickly. Stack gold and reputation rapidly. Choose and upgrade 36 perks blessed by 12 Gods/saints. Become the Legend of the Kingdoms.
Tower DefenseMinimalistStrategyRogueliteRelaxingSingleplayerAtmosphericCasualIndie3D
$1.99Critter Chaos TD
Oct 31 · Chaos Creations
Both: Tower Defense · RTS
Critter Chaos TD is a fast, frantic and chaotic Tower Defence game in which you must rid the world of the evil Critters. Build stations and guns to fortify your defences and prevent the various types of Critters from reaching your base.
StrategyAction RTSWargameTower DefenseRTSEarly AccessCasualActionIndieBase Building
FreeFortress Fury
Jan 21 · Kervado
Both: Tower Defense
Fortress Fury is a survivor multiplayer tower defense roguelite. Endless hordes of enemies want to crush your tower! Buy weapons and upgrades to craft an array of overpowering builds. Will you be able to survive all waves and be the last tower?
StrategyActionTower DefenseBullet HellRoguelite2DTop-DownCuteColorfulMagic
$14.99Mechabellum
Sep 26 · Game River
Both: RTS
Command massive armies in this epic mech auto-battler. Draft your troops, customize your units, master your formations, and crush enemies in spectacular 3D battles. All strategy, no clickfest. Outsmart opponents in 1v1, 2v2, free-for-all, or Survival Mode.
StrategyAuto BattlerMechsRobotsWargameTacticalPvPMultiplayerRTSTurn-Based Strategy👍 17,866
-15%$1.69Card Shelter Defence
4 days ago · NeographGamer
Both: Tower Defense
Recruit cards, assign them to shelters, and stop incoming waves in a strategic tower defense game. Combine three cards to strengthen your forces, manage limited resources, and adapt to each scenario.
StrategyTower Defense2DSingleplayerCard BattlerFamily FriendlyResource ManagementIndie
$12.99Block Tower TD 2
Jul 19 · MyDreamForever, Tazdraperm
Both: Tower Defense
Block Tower TD 2 is a strategic game in the roguelike style with original innovations. Build worlds from blocks, choose random upgrades, each game will be unique.
Tower DefenseCuteSandboxStrategyRoguelikeRogueliteFantasyHand-drawnCity Builder2D
-20%$15.99SENTRY
Mar 25 · Fireblade Software
Both: Tower Defense
SENTRY is an action-defense first person shooter where you defend your spaceship against invading aliens. Plot an escape route through hostile space and battle the enemy across your vessel with the support of traps, turrets and environmental destruction.
Tower DefenseStrategyFPSSci-fiSurvivalActionColorfulStylized3DFirst-Person👍 847
$14.99Gems Defenders
Aug 30 · Tesaks Entertainment s.r.o.
Both: Tower Defense · Puzzle
Match 3 Game, Tower Defense Game and Story driven RPG. Gems Defenders have it all! Match enchanted gems to power up your town, heal your heroes, charge powerful spells, defeat the enemies that are storming the gates of your city and uncover lore of the mysterious Aldenor!
Match 3Tower DefensePixel GraphicsAction2DAdventureMedievalColorfulMagicPuzzle
-15%$8.49Crown Siege
3 days ago · JOrbits Games
Both: Tower Defense
A short incremental siege game centered around growing and strengthening an army to defend your kingdom. Seize the crown from an endless wave of enemies for your best chance at survival!
IncrementalAuto BattlerTower DefenseCasualIdlerActionHack and SlashMedievalSimulationStrategy
$29.99Diplomacy is Not an Option
Oct 4 · Door 407
Both: RTS
Diplomacy is Not an Option is a strategy game set in a medieval fantasy world. Build your town and defenses, raise huge armies and fight against massive hordes of enemies. How long can you survive?
Resource ManagementMedievalHistoricalZombiesBase BuildingColony SimRTSDifficultAction RTSSurvival👍 10,910
-15%$4.24Demonic Defense
4 days ago · xHo
Both: Tower Defense
Guard your campfire through the night and feed your rivals' rifts with monsters. A multiplayer tower-defense survival hybrid where deck building, base building, and dueling economies decide who survives and who freezes.
Early AccessCard BattlerTower DefenseReal Time TacticsAction RoguelikeTrading Card GamePvEPvPStrategyTutorial
$4.99Samawa Idle
Nov 13 · Samharia Studios
Both: Tower Defense
Unleash the power of specialized towers to annihilate hordes of monsters in this idle game with roguelike elements. Collect gold, level up your towers, face powerful bosses, and refine your strategy with an evolving skill tree.
IncrementalIdlerRogueliteAuto BattlerTower DefenseRPGRoguelikeCharacter Customization2DTop-Down👍 600
-50%$7.49HexaScape: Cyber Defense
Jan 29 · Clockwork Origins
Both: Tower Defense · Puzzle
Build your perfect defenses with hexagons! Use hex tiles to explore cyberspace, upgrade your defense towers, and complete quests in this unique turn-based strategy game. With a campaign, a procedurally generated endless mode, and a powerful editor, HexaScape offers endless challenges.
SimulationTurn-Based StrategyHex GridStrategyBoard GameTower DefenseSandboxPuzzleExplorationLevel Editor
$24.99Outpost: Infinity Siege
Mar 26 · Team Ranger
Both: Tower Defense
Command Mobile Outpost and take XEN Firearm to venture deep into the Signet surveillance off-limit area. Collect unique Weapon Units. Amp up the firepower of the Outpost that fights with you. This is an FTD game - FPS, Tower Defense, Base Building and much more all at the same time.
Robots3DTower DefenseBase BuildingFPSResource ManagementCo-opSingleplayerPost-apocalypticSci-fi👍 11,637
FreeFrom Them
May 30 · JJTheJetPlane27
Both: Tower Defense
A short first person wave defense surrounding mutant creatures invading your town. Collect materials and fire power from the hardware and gun store, build traps to defend yourself, and survive 6 nights. Comes with Unreal Engine 5 project files.
HorrorActionFPSTower DefenseDarkAtmosphericFirst-PersonStylizedCombatFree to Play
$19.99The Front
Oct 30 · Samar Studio
Both: Tower Defense
The Front is a survival open-world crafting sandbox game. You are a resistance fighter sent back in time to stop the rise of a tyrannical empire. Collect resources, craft tech, build shelters, and fight monsters to accomplish your mission.
Open World Survival CraftMultiplayerSurvivalCraftingBase BuildingBuildingOpen WorldTower DefenseSandboxShooter👍 9,553
$4.99Doom Sweeper
Jun 8 · Paper Dog
Both: Tower Defense
DOOM SWEEPER is a 2D pixel-style game. Clean up the approaching zombie climax, and exchange it for cash, embarking on a journey to become an arms dealer in the apocalypse. Complete the game, unlock more items in the shop, and achieve various achievements to obtain different CG!
Action RoguelikeHack and SlashTower DefenseIdlerRogueliteRoguelikeStrategyRPGPost-apocalyptic2D👍 782
$4.99Dungeon Keeper™ 2
Mar 7 · Bullfrog Productions
Both: RTS
Bad guys have all the fun. Discover your dark side as you build an evil underground kingdom and defend it against the forces of good.
StrategyGod GameAction RPGSingleplayerReal Time TacticsActionVillain ProtagonistRTSClassicBase Building👍 1,253
$2.50OmniSeed
Jul 13 · Velest
Both: Tower Defense
Play as a kind-hearted god in a tiny world. Grow thriving forests, inspire mortals to stand strong, and unleash nature's fury to shield them from evil. One small miracle at a time.
RogueliteTower DefenseGod GameDeckbuildingCard BattlerTacticalPixel Graphics2DTop-DownSingleplayer
$19.99Becastled
Oct 22 · Mana Potion Studios
Both: RTS
Build a castle by day and defend it by night. Becastled blends cozy city-building with challenging tower defense strategy. Lead the Sun Kingdom’s last stand against the Moon Beasts and end the ancient conflict between light and darkness!
Base BuildingStrategyCity BuilderMedievalBuildingRTSColony SimWarMilitarySingleplayer👍 5,352
FreeThe Perfect Tower II
Nov 30 · Fire Sword Studios
Both: Tower Defense
The Perfect Tower II is a mix between an incremental and a tower defense game. Build a town, manage resources and explore a variety of mini-games and tons of upgrades. Fully automate your game and watch numbers going up!
Tower DefenseIdlerStrategyAutomationResource ManagementActionMinigamesVoxelBase BuildingIncremental
$3.99Last Hope: Zombie Autobattler
Jul 27 · Hands-Off Games
Both: Tower Defense
Build your towers and let them do the killing! Connect 12 unique towers through the Reactor to discover 144 devastating synergies. Kill endless zombie hordes, mutate them for bigger rewards, and push your build to the limit in a chaotic bullet hell.
Tower DefenseIdlerZombiesBullet HeavenRogueliteRoguelikeResource ManagementSurvivalPost-apocalypticStrategy
$1.00Dealer's Dice
Sep 7 · OFFMOON Inc.
Both: Tower Defense
Trapped in the twisted game room of a mysterious entity, Dealer's Dice is a high-stakes roguelike dice-defense game. Collect powerful dice, manage your betting table, and gamble against relentless waves of invaders. Push your luck, test your greed, and survive.
Tower DefenseIncrementalCasualDiceRoguelikeRogueliteStrategyChoices MatterIndieArcade
$3.99The Last Braincell
Feb 16 · Seaweaver
Both: Puzzle · Cartoony
Do you ever want to revisit the good old days of bouncing screen savers? Well not only can you do that you can also add whatever images you'd like to it, customize its background to whatever you'd want it to be, and even play around with them as you brain blast your last few brain cells!
SingleplayerStrategyCasualArcadeBoard GamePuzzleTurn-Based Strategy2.5DCartoonyColorful
-80%$2.99Legendary Hoplite
Feb 2 · TripleBricksGames
Both: Tower Defense
A combination of Action RPG and Tower Defense: slay monsters, find weapons, upgrade your armies, defend your base… Prevent humanity from extinction at the hands of monsters from Greek mythology and ancient tribes. Don't let them cross the gate, commander!
Strategy RPGRogueliteAdventureTower DefenseAction RPGHack and SlashReal Time TacticsSurvivalTacticalAction👍 335







