PlayfeedGames like Mainframe Defenders
by Synthetic Domain
Mainframe Defenders is an isometric 2D sci-fi tactical RPG: defend mainframe, destroy unit fabricators and download data. Into the Breach and BATTLETECH play most like Mainframe Defenders. Of the 12 closest games below, most share its roguelike and roguelite.
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Ranked by how similar the games actually are, not by sales. Released and Price are remembered for next time.
Closest matches
Into the Breach
Feb 27, 2018 · Subset Games
Both: Mechs · Roguelike · Roguelite
Isometric 2D sci-fi turn-based strategy roguelike, pixel graphics. Controlling mechs, defending cities and fighting alien creatures.
StrategyTurn-Based StrategyIndiePixel GraphicsTurn-Based TacticsMechsRoguelikePuzzleTurn-BasedRoguelite👍 19,053Star Renegades
Sep 8, 2020 · Massive Damage, Inc.
Both: Roguelike · Roguelite · Tactical RPG
2D sci-fi tactical turn-based roguelite RPG, pixel graphics. Turn-based tactical combat, procedural mission exploration, squad management and upgrades.
Dialogue HeavyRoguelikePixel GraphicsTurn-BasedRogueliteSingleplayerJRPGTactical RPGMechsRPG👍 2,677Templar Battleforce
Sep 21, 2015 · Trese Brothers
Both: Tactical RPG · Roguelike
Top-down 2D sci-fi turn-based tactical RPG, detailed pixel art. Strategic combat, army building and character customization.
Turn-Based TacticsTactical RPGPerma DeathDifficultTurn-BasedTurn-Based StrategyStrategy RPG2DCharacter CustomizationRoguelike👍 931Stellar Tactics
Mar 30 · Don Wilkins
Both: Exploration · Tactical RPG · Sandbox
Isometric 3D sci-fi tactical RPG. Turn-based ground battles, space exploration, trading and mining.
CRPGExplorationTactical RPGTurn-Based TacticsDungeon CrawlerSandboxParty-Based RPGCharacter CustomizationRPGIsometric👍 1,678Mainframe Defenders: Meltdown - Prologue
Jun 2, 2021 · Synthetic Domain
Both: Roguelike
Top-down 2D sci-fi tactical turn-based strategy, 80s terminal pixel graphics. Protect the mainframe, destroy fabricators and download data.
Singleplayer2DStrategyJRPGTurn-Based CombatAtmosphericRoguelikeTurn-Based StrategyPixel GraphicsTurn-Based TacticsStarVaders
Apr 30, 2025 · Pengonauts
Both: Roguelite · Roguelike
Top-down 2D sci-fi roguelike deckbuilder, colorful cartoonish. Deckbuilding, tactical grid-based combat and card battling.
Roguelike DeckbuilderDeckbuildingTurn-Based TacticsRogueliteDifficultVisual NovelCard GameTurn-Based StrategyRoguelikeBoard Game👍 3,770