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Games like Plague Inc: Evolved

by Ndemic Creations

Plague Inc: Evolved is a top-down 3D modern-day strategy simulation: evolving pathogens, infecting the world and competing in multiplayer. Bio Inc. Redemption and Infectonator 3: Apocalypse play most like Plague Inc: Evolved. Of the 12 closest games below, most share its outbreak sim.

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Ranked by how similar the games actually are, not by sales. Released and Price are remembered for next time.

Closest matches

Bio Inc. Redemption
Mar 8, 2018 · DryGin Studios
Both: Outbreak Sim
2D modern-day medical simulation strategy. Creating diseases, diagnosing and curing illnesses, managing medical strategies.
Medical SimOutbreak SimSimulationStrategyManagementGoreSandboxSingleplayerMultiplayerAtmospheric👍 3,063
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Infectonator 3: Apocalypse
May 10, 2018 · Toge Productions
Both: Outbreak Sim · Zombies
Top-down 2D modern-day simulation-strategy, pixelart mayhem. Upgrade virus, splice DNA and destroy humanity.
Outbreak SimIndieZombiesStrategySimulationSingleplayerPixel GraphicsDifficultVillain ProtagonistComedy👍 1,254
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Infectious
Aug 20, 2020 · Ziggy Makes Games
Both: Outbreak Sim
Top-down 2D sci-fi outbreak simulation survival horror, hand-drawn microscopic. Infecting organs, mutating DNA and outrunning immune system.
Outbreak SimSurvival HorrorSimulationScienceStealthRunnerRealisticAtmosphericArcadeSurvival
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Extinction Day
Apr 10 · DryGin Studios
Both: Outbreak Sim
Top-down 3D modern-day god game simulation, digital sci-fi interface. Deploying disasters, managing resources and triggering chain reactions.
Outbreak SimReal-Time with PauseSimulationGod GameResource ManagementSandboxPolitical SimManagementDystopian Destruction👍 212
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Rebel Inc: Escalation
Oct 13, 2021 · Ndemic Creations
Both: Tactical
Top-down 3D modern-day political/military strategic simulation, realistic satellite-style. Stabilizing regions, managing resources and countering insurgency.
StrategySimulationGrand Strategy4XHistoricalWarEconomyTacticalManagementDiplomacy👍 6,949
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Propa.
Apr 27, 2025 · ValarFerys
Both: Outbreak Sim
Top-down 2D RTS outbreak simulation, minimalist abstract. Commanding viruses, replicating in cells and evading immune systems.
StrategyRTSMinimalistPhysicsModdableMedical SimOutbreak SimNonlinearAbstractLogic
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GlobalQuarantine
Jun 2, 2025 · ValarFerys
Both: Outbreak Sim
2D modern-day simulation strategy, flat 2D illustration. Managing global health, building headquarters and making political decisions.
CasualSimulationStrategyMedical SimIdlerPolitical SimOutbreak Sim2DText-BasedDystopian
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Supreme Ruler Global Outbreak
Apr 24, 2025 · BattleGoat Studios
Both: Zombies · Outbreak Sim
Top-down 3D post-apocalyptic grand strategy RTS, realistic satellite map. Managing nations, military combat, diplomacy and trade.
ZombiesSingleplayerSimulationStrategyOutbreak SimPost-apocalypticSurvivalGrand StrategyRTSPolitical Sim
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ICBM
Nov 17, 2020 · SoftWarWare, K-Project
Both: Outbreak Sim · Tactical
Top-down 3D modern-day real-time strategy, realistic digital map. Research technologies, build nuclear stockpile and launch missile strikes.
RTSCold WarMilitaryDestructionStrategyReal Time TacticsWarOutbreak SimPvPTactical👍 1,655
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The Override Protocol
Sep 16 · SergTech2000
Both: Outbreak Sim
Top-down 3D sci-fi cinematic RTS grand strategy. Spreading across a globe, managing resources and evolving AI.
Outbreak SimStrategyEspionageArtificial IntelligenceHackingDifficultSimulationRTSGrand StrategyChoices Matter
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Pandemic: The Board Game
Aug 24, 2018 · Asmodee Digital
Both: Outbreak Sim
Top-down 2D modern-day co-op board game simulation, digital painted art. Treating diseases, discovering cures and containing infections.
StrategySimulationBoard GameOutbreak SimTabletopMedical SimCo-opSingleplayerTurn-BasedCard Game👍 414
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Infestation: The New Beginning
· Fredaikis AB
Both: Zombies
First-person 3D post-apocalyptic survival action RPG, realistic 3D. Explore, scavenge and survive.
ZombiesSurvivalMassively MultiplayerOpen WorldActionPvPMultiplayerRPGIndieFPS👍 17,107
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