PlayfeedGames like Genome Guardian
by Alpherior
Genome Guardian is a top-down 2D sci-fi action roguelike shooter: shooting microbes, combining DNA for weapons and researching permanent upgrades. Pathogenic and Nova Drift play most like Genome Guardian. Of the 12 closest games below, most share its action roguelike, roguelite and roguelike.
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Ranked by how similar the games actually are, not by sales. Released and Price are remembered for next time.
Closest matches
Pathogenic
Jul 16 · Aberrant Labs
Both: Roguelike · Top-Down Shooter · Action Roguelike
Top-down 2D sci-fi action roguelike twin-stick shooter, colorful soft-body organic. Fighting the immune system, evolving via organelle grafting and upgrading via metaprogression.
RoguelikeBullet HellTop-Down ShooterLocal Co-OpBullet HeavenAction RoguelikeDifficultDungeon CrawlerShooterCharacter Customization👍 4,308Nova Drift
Aug 12, 2024 · Chimeric
Both: Roguelite · Action Roguelike · Shooter
Top-down 2D sci-fi action roguelike space shooter, neon arcade aesthetic. Shooting enemies, building custom ship upgrades and surviving waves.
Shoot 'Em UpBullet HellRogueliteArcadeAction RoguelikeArena ShooterAction RPGBullet HeavenShooterRoguelike👍 13,00320 Minutes Till Dawn
Jun 8, 2023 · flanne
Both: Action Roguelike · Survival · Roguelite
Top-down 2D fantasy action roguelike bullet hell, pixel graphics. Surviving hordes of monsters, creating dynamic builds, collecting upgrades and experience.
Action RoguelikeBullet HellSurvivalRogueliteShoot 'Em UpHorrorTop-Down ShooterCombatPixel GraphicsLovecraftian👍 27,896SYNTHETIK: Legion Rising
Mar 15, 2018 · Flow Fire Games
Both: Top-Down Shooter · Roguelite · Action Roguelike
Top-down 3D sci-fi action roguelike twin stick shooter, stylized low poly. Combat with various weapons, customizing character classes, collecting items and perks.
Top-Down ShooterRogueliteIndieAction RoguelikeActionOnline Co-OpDifficultCo-opTwin Stick ShooterShooter👍 10,110Nuclear Throne
Dec 5, 2015 · Vlambeer
Both: Action Roguelike · Roguelike · Roguelite
2D post-apocalyptic top-down shooter roguelike, pixel graphics. Fighting through wastelands, collecting radiation, mutating limbs and abilities.
Action RoguelikeRoguelikePixel GraphicsIndieDifficultBullet HellActionRogueliteTop-Down ShooterGreat Soundtrack👍 15,056Magicraft
Nov 1, 2024 · Wave Games
Both: Action Roguelike · Roguelite · Roguelike
Top-down 2D fantasy action roguelike, dark spoof cartoon. Combining spells, battling monsters and solving puzzles.
Action RoguelikeRogueliteBullet HellLooter ShooterRoguelikeStrategy RPGRPGTop-DownDeckbuildingProcedural Generation👍 15,100Slime 3K: Rise Against Despot
Oct 31, 2024 · Konfa Games
Both: Action Roguelike · Roguelite · Roguelike
Top-down 2D sci-fi action roguelike deckbuilder, pixel art. Surviving enemy onslaughts, deckbuilding with cards, upgrading weapons and traits.
Action RoguelikeBullet HellDeckbuildingRogueliteRoguelike2DShoot 'Em UpTop-Down ShooterHack and SlashShooter👍 1,595SULFUR
Oct 28, 2024 · Perfect Random
Both: Gun Customization · Action Roguelike · Shooter
First-person 3D fantasy roguelite boomer shooter, stylized low poly. Combat, exploration and loot collection.
Gun CustomizationAction RoguelikeExtraction ShooterFPSSingleplayerDungeon CrawlerShooterRogueliteDifficultRoguelike👍 9,715The Binding of Isaac
Sep 28, 2011 · Edmund McMillen, Florian Himsl
Both: Action Roguelike · Roguelike
Top-down 2D action roguelike RPG shooter, dark hand-drawn cartoon. Fighting enemies, collecting items and exploring dungeons.
Action RoguelikeRoguelikeIndieReplay ValueDifficultProcedural GenerationDarkActionTop-DownGreat Soundtrack👍 49,234Swarm Grinder
Apr 22, 2024 · Last Bite Games
Both: Roguelike · Roguelite · Action Roguelike
Top-down 2D sci-fi action roguelike, pixel graphics. Fighting alien bugs, collecting upgrade parts and building skill synergies.
RoguelikeRogueliteAction RoguelikeBullet HellMechsProcedural Generation2DPixel GraphicsControllerAction RPG👍 1,167Pesticide Not Required
Mar 18, 2024 · Jampacked Games
Both: Action Roguelike · Roguelite · Top-Down Shooter
Top-down 2D action roguelike bullet hell, colorful cartoon 2D. Fighting insect hordes, farming crops, fishing and mining.
Action RoguelikeBullet HellRogueliteShoot 'Em UpAction RPGTop-Down ShooterFarming SimActionTwin Stick ShooterSingleplayer👍 817Genome Guardian 2
Mar 5 · Alpherior
Both: Gun Customization · Roguelite · Top-Down Shooter
Top-down 2D sci-fi action roguelite bullet heaven, colorful bioluminescent microscopic. Building biomechanical weapons, surviving microbe waves and collecting resources.
Gun CustomizationBullet HeavenRogueliteActionCasualTwin Stick ShooterTop-Down ShooterShooterScienceAction Roguelike👍 414