PlayfeedGames like Genome Guardian 2
by Alpherior
Genome Guardian 2 is a top-down 2D sci-fi action roguelite bullet heaven: building biomechanical weapons, surviving microbe waves and collecting resources. Genome Guardian and Pathogenic play most like Genome Guardian 2. Of the 12 closest games below, most share its roguelite, bullet heaven and top-down shooter.
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Ranked by how similar the games actually are, not by sales. Released and Price are remembered for next time.
Closest matches
Genome Guardian
May 7, 2024 · Alpherior
Both: Shooter · Roguelite · Gun Customization
Top-down 2D sci-fi action roguelike shooter, colorful bioluminescent. Shooting microbes, combining DNA for weapons and researching permanent upgrades.
Action RoguelikeShooterRogueliteGun CustomizationRoguelikeTop-Down ShooterSurvivalScienceAtmosphericColorful👍 711Pathogenic
Jul 16 · Aberrant Labs
Both: Top-Down Shooter · Bullet Heaven · Shooter
Top-down 2D sci-fi action roguelike twin-stick shooter, colorful soft-body organic. Fighting the immune system, evolving via organelle grafting and upgrading via metaprogression.
RoguelikeBullet HellTop-Down ShooterLocal Co-OpBullet HeavenAction RoguelikeDifficultDungeon CrawlerShooterCharacter Customization👍 4,308NIMRODS
Oct 28, 2024 · Fiveamp
Both: Bullet Heaven · Gun Customization · Roguelite
Top-down 2D sci-fi action roguelite shooter, pixel art. Crafting weapons, fighting alien hordes and evolving DNA.
Bullet HeavenAction RoguelikeBullet HellGun CustomizationRogueliteActionRoguelikeRPGSingleplayerEarly Access👍 1,786Nova Drift
Aug 12, 2024 · Chimeric
Both: Roguelite · Shooter
Top-down 2D sci-fi action roguelike space shooter, neon arcade aesthetic. Shooting enemies, building custom ship upgrades and surviving waves.
Action RoguelikeArena ShooterBullet HellShoot 'Em UpRogueliteArcadeShooter2DRoguelikeAction RPG👍 13,003Survivors of the Dawn
Nov 6, 2023 · indieGiant
Both: Bullet Heaven · Top-Down Shooter · Twin Stick Shooter
Top-down 3D sci-fi action roguelike bullet heaven. Fighting hordes, mixing weapons with items and upgrading weapons.
Early AccessAction RoguelikeBullet HeavenBullet HellTop-Down ShooterSci-fiTwin Stick ShooterCasualRogueliteShooter👍 697Deep Rock Galactic: Survivor
Sep 17, 2025 · Funday Games
Both: Bullet Heaven · Roguelite · Top-Down Shooter
Top-down 3D sci-fi action roguelike, stylized 3D. Kill aliens, mine riches and upgrade gear.
DwarvesAction RoguelikeBullet HeavenRogueliteBullet HellTop-Down ShooterPvETop-DownArena ShooterProcedural Generation👍 46,417Void Scrappers
Oct 21, 2022 · 8BitSkull
Both: Bullet Heaven · Top-Down Shooter · Roguelite
Top-down 2D sci-fi action roguelike bullet heaven, pixel art. Collect scrap, upgrade ship and fight bosses.
Action RoguelikeBullet HeavenTop-Down ShooterShoot 'Em UpActionRogueliteLootRoguelikeBullet HellScore Attack👍 571Run Build Pew!
Jun 6, 2022 · Knight Owl Games
Both: Bullet Heaven · Roguelite · Top-Down Shooter
Top-down 2D sci-fi action roguelite shooter, colorful 2D cartoon. Building ships, shooting enemies and collecting scraps.
Bullet HeavenRogueliteAction RoguelikeTop-Down ShooterSpaceShoot 'Em UpShooterArcadeRoguelike2D👍 553Survivesmith
Sep 29 · Stardust-Forge Games
Both: Bullet Heaven · Roguelite · Top-Down Shooter
Top-down 2D sci-fi bullet heaven roguelite, cute 2D art. Crafting, resource gathering and fighting hordes.
Early AccessBullet HeavenBullet HellRogueliteTop-Down ShooterCuteRoguelikeAction RoguelikeSci-fiCraftingSoulstone Survivors
Jun 17, 2025 · Game Smithing Limited
Both: Bullet Heaven · Roguelite
Top-down 2D fantasy action roguelite. Obliterating hordes of enemies, battling colossal bosses and crafting unique weapons.
Bullet HeavenAction RoguelikeBullet HellRogueliteAction RPGRoguelikeCraftingRPGHack and SlashAction👍 25,774Pesticide Not Required
Mar 18, 2024 · Jampacked Games
Both: Roguelite · Top-Down Shooter · Twin Stick Shooter
Top-down 2D action roguelike bullet hell, colorful cartoon 2D. Fighting insect hordes, farming crops, fishing and mining.
Action RoguelikeBullet HellRogueliteShoot 'Em UpAction RPGTop-Down ShooterFarming SimActionTwin Stick ShooterSingleplayer👍 817