PlayfeedGames like Pathogenic
by Aberrant Labs
Pathogenic is a top-down 2D sci-fi action roguelike twin-stick shooter: fighting the immune system, evolving via organelle grafting and upgrading via metaprogression. HyperParasite and Genome Guardian 2 play most like Pathogenic. Of the 12 closest games below, most share its action roguelike and bullet hell.
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Ranked by how similar the games actually are, not by sales. Released and Price are remembered for next time.
Closest matches
HyperParasite
Apr 3, 2020 · Troglobytes Games
Both: Dungeon Crawler · Shooter · Difficult
Top-down 2D sci-fi twin stick roguelite shooter, grungy synthwave. Snatching hosts, fighting bosses and collecting upgrades.
Twin Stick ShooterDungeon CrawlerRogueliteShooterPerma DeathProcedural GenerationDifficultFunnyTop-DownRoguelikeGenome Guardian 2
Mar 5 · Alpherior
Both: Bullet Heaven · Top-Down Shooter · Shooter
Top-down 2D sci-fi action roguelite bullet heaven, colorful bioluminescent microscopic. Building biomechanical weapons, surviving microbe waves and collecting resources.
Early AccessGun CustomizationBullet HeavenRogueliteActionCasualTwin Stick ShooterTop-Down ShooterShooterScience👍 414Genome Guardian
May 7, 2024 · Alpherior
Both: Action Roguelike · Shooter · Roguelike
Top-down 2D sci-fi action roguelike shooter, colorful bioluminescent. Shooting microbes, combining DNA for weapons and researching permanent upgrades.
Action RoguelikeShooterRogueliteGun CustomizationRoguelikeTop-Down ShooterSurvivalScienceAtmosphericColorful👍 711Science Monster: Grafted Heart
Sep 29 · JIELIN
Both: Action Roguelike · Shooter · Top-Down Shooter
Top-down 2D post-apocalyptic action roguelite survival, dark horror. Grafting organs, surviving combat and building mutations.
ActionStrategyAction RoguelikeShooter2D PlatformerTop-Down ShooterBullet Hell2DTop-DownPost-apocalypticBioweaver
Nov 15, 2024 · Emprom Game, Wild Kid Games
Both: Bullet Hell · Character Customization
Top-down 2D sci-fi action RPG, pixel graphics. Programming organ links, mutating organs and fighting creatures.
ProgrammingTactical RPGLooter ShooterAction RPGHack and SlashBullet HellDeckbuildingCharacter CustomizationAutomation2D👍 669Bioprototype
May 19, 2025 · Emprom Game
Both: Bullet Hell · Roguelike · Action Roguelike
2D sci-fi action roguelike, pixel graphics. Programming skill logics, combat and building organ combos.
Bullet HellProgrammingRogueliteDeckbuildingVampiresPixel GraphicsRoguelikeTactical RPGAction RoguelikeHack and SlashNova Drift
Aug 12, 2024 · Chimeric
Both: Bullet Hell · Action Roguelike · Bullet Heaven
Top-down 2D sci-fi action roguelike space shooter, neon arcade aesthetic. Shooting enemies, building custom ship upgrades and surviving waves.
Shoot 'Em UpBullet HellRogueliteArcadeAction RoguelikeArena ShooterAction RPGBullet HeavenShooterRoguelike👍 13,003Brotato
Jun 23, 2023 · Blobfish
Both: Roguelike · Bullet Hell · Action Roguelike
Top-down 2D sci-fi action roguelike, cartoonish 2D. Survive waves, kill aliens and collect materials.
RoguelikeSingleplayerBullet HellAction RoguelikeLocal Co-OpBullet HeavenMultiplayerSurvivalArena ShooterRoguelite👍 111,69120 Minutes Till Dawn
Jun 8, 2023 · flanne
Both: Action Roguelike · Bullet Hell · Top-Down Shooter
Top-down 2D fantasy action roguelike bullet hell, pixel graphics. Surviving hordes of monsters, creating dynamic builds, collecting upgrades and experience.
Action RoguelikeBullet HellSurvivalRogueliteShoot 'Em UpHorrorTop-Down ShooterCombatPixel GraphicsLovecraftian👍 27,896Vampire Survivors
Oct 20, 2022 · poncle
Both: Action Roguelike · Bullet Hell · Roguelike
Top-down 2D fantasy action roguelike bullet hell, pixel graphics. Surviving waves of enemies, collecting gems and items, buying character upgrades.
Action RoguelikeBullet HellVampiresRoguelitePixel Graphics2DIndieSingleplayerCasualRoguelike👍 251,906Nuclear Throne
Dec 5, 2015 · Vlambeer
Both: Action Roguelike · Roguelike · Difficult
2D post-apocalyptic top-down shooter roguelike, pixel graphics. Fighting through wastelands, collecting radiation, mutating limbs and abilities.
Action RoguelikeRoguelikePixel GraphicsIndieDifficultBullet HellActionRogueliteTop-Down ShooterGreat Soundtrack👍 15,056SYNTHETIK: Legion Rising
Mar 15, 2018 · Flow Fire Games
Both: Top-Down Shooter · Action Roguelike · Difficult
Top-down 3D sci-fi action roguelike twin stick shooter, stylized low poly. Combat with various weapons, customizing character classes, collecting items and perks.
Top-Down ShooterRogueliteIndieAction RoguelikeActionOnline Co-OpDifficultCo-opTwin Stick ShooterShooter👍 10,110