PlayfeedGames like Vitro : Bloodstream
by Drew VanWagner
Vitro : Bloodstream is a top-down 2D sci-fi action roguelike: neutralize biological threats, collect bio energy and upgrade probe. Genome Guardian and Pathogenic play most like Vitro : Bloodstream. Of the 12 closest games below, most share its action roguelike.
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Ranked by how similar the games actually are, not by sales. Released and Price are remembered for next time.
Closest matches
Genome Guardian
May 7, 2024 · Alpherior
Both: Action Roguelike
Top-down 2D sci-fi action roguelike shooter, colorful bioluminescent. Shooting microbes, combining DNA for weapons and researching permanent upgrades.
Action RoguelikeShooterRogueliteGun CustomizationRoguelikeTop-Down ShooterSurvivalScienceAtmosphericColorful👍 711Pathogenic
Jul 16 · Aberrant Labs
Both: Action Roguelike
Top-down 2D sci-fi action roguelike twin-stick shooter, colorful soft-body organic. Fighting the immune system, evolving via organelle grafting and upgrading via metaprogression.
RoguelikeBullet HellTop-Down ShooterLocal Co-OpBullet HeavenAction RoguelikeDifficultDungeon CrawlerShooterCharacter Customization👍 4,308Science Monster: Grafted Heart
Sep 29 · JIELIN
Both: Action Roguelike · Top-Down
Top-down 2D post-apocalyptic action roguelite survival, dark horror. Grafting organs, surviving combat and building mutations.
ActionStrategyAction RoguelikeShooter2D PlatformerTop-Down ShooterBullet Hell2DTop-DownPost-apocalypticNova Drift
Aug 12, 2024 · Chimeric
Both: Action Roguelike · Arcade
Top-down 2D sci-fi action roguelike space shooter, neon arcade aesthetic. Shooting enemies, building custom ship upgrades and surviving waves.
Action RoguelikeArena ShooterBullet HellShoot 'Em UpRogueliteArcadeShooter2DRoguelikeAction RPG👍 13,003The Binding of Isaac
Sep 28, 2011 · Edmund McMillen, Florian Himsl
Both: Action Roguelike · Top-Down
Top-down 2D action roguelike RPG shooter, dark hand-drawn cartoon. Fighting enemies, collecting items and exploring dungeons.
Action RoguelikeRoguelikeIndieReplay ValueDifficultProcedural GenerationDarkActionTop-DownGreat Soundtrack👍 49,23420 Minutes Till Dawn
Jun 8, 2023 · flanne
Both: Action Roguelike
Top-down 2D fantasy action roguelike bullet hell, pixel graphics. Surviving hordes of monsters, creating dynamic builds, collecting upgrades and experience.
Action RoguelikeBullet HellSurvivalRogueliteShoot 'Em UpHorrorTop-Down ShooterCombatPixel GraphicsLovecraftian👍 27,896SYNTHETIK: Legion Rising
Mar 15, 2018 · Flow Fire Games
Both: Action Roguelike
Top-down 3D sci-fi action roguelike twin stick shooter, stylized low poly. Combat with various weapons, customizing character classes, collecting items and perks.
Top-Down ShooterRogueliteIndieAction RoguelikeActionOnline Co-OpDifficultCo-opTwin Stick ShooterShooter👍 10,110Starforged Legacy
Jun 1 · Second Shift Games
Both: Action Roguelike · PvE · Arcade
Top-down 3D sci-fi action roguelike bullet heaven. Combat against swarms, ship customization and galactic navigation.
Early AccessAction RoguelikeTop-Down ShooterBullet HellBullet HeavenRoguelitePvEArcadeRoguelikeStrategy👍 174Hades
Sep 17, 2020 · Supergiant Games
Both: Action Roguelike
Isometric 2D fantasy action roguelike dungeon crawler, hand-painted environments. Combat, escaping the underworld and building character relationships.
Action RoguelikeRogueliteHack and SlashIndieMythologyActionRoguelikeSingleplayerGreat SoundtrackStory Rich👍 286,004