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Games like Immune Commander

by BT STUDIO

Pathogenic and Total War: SHOGUN 2 play most like Immune Commander. Of the 15 closest games below.

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Ranked by how similar the games actually are, not by sales. Released and Price are remembered for next time.

Closest matches

Pathogenic
Jul 16 · Aberrant Labs
Top-down 2D sci-fi action roguelike twin-stick shooter, colorful soft-body organic. Fighting the immune system, evolving via organelle grafting and upgrading via metaprogression.
RoguelikeBullet HellTop-Down ShooterLocal Co-OpBullet HeavenAction RoguelikeDifficultDungeon CrawlerShooterCharacter Customization👍 4,308
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Total War: SHOGUN 2
· The Creative Assembly
Third-person 3D historical grand strategy RTS. Turn-based strategy, real-time tactics and diplomacy.
StrategyHistoricalTurn-Based StrategyRTSGrand StrategyTacticalSingleplayerReal Time TacticsMultiplayerDiplomacy👍 38,168
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Defend the Rook
Oct 26, 2021 · One Up Plus
Isometric 2D fantasy turn-based strategy, stylized colorful 2D. Defending and battling.
IndieRPGStrategy👍 189
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Tower Dominion
May 7, 2025 · Parallel 45 Games
Isometric 3D sci-fi tower defense strategy, stylized low-poly. Building defenses, managing resources and modifying terrain.
Tower DefenseStrategyBase BuildingRoguelikeRTSTacticalRogueliteChoices MatterProcedural GenerationResource Management👍 5,147
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Propa.
Apr 27, 2025 · ValarFerys
Top-down 2D RTS outbreak simulation, minimalist abstract. Commanding viruses, replicating in cells and evading immune systems.
StrategyRTSMinimalistPhysicsModdableMedical SimOutbreak SimNonlinearAbstractLogic
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Rogue Tower
Jan 28, 2022 · Die of Death Games
Isometric 3D fantasy tower defense roguelike, minimalist, colorful, voxel-like. Building towers, upgrading towers and expanding the path.
Tower DefenseStrategyRoguelikeCasualProcedural Generation3DMinimalistBase BuildingRogueliteSingleplayer👍 5,776
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EverSiege: Untold Ages
Mar 26 · Tindalos Interactive
Top-down 3D fantasy strategy rogue-lite. Summoning troops, building and completing quests.
Action RTSRogueliteMOBACo-opPvETower DefenseSurvivalStrategyOnline Co-OpRTS👍 1,933
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Rogue Command
May 14 · feneq
Top-down 3D sci-fi action RTS roguelite. Control units, build base and harvest resources.
RTSAction RTSSci-fiBullet TimeProcedural GenerationRogueliteFuturisticStrategyRoguelikeAction👍 1,020
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Axon TD: Uprising - Tower Defense
Sep 27, 2024 · Element Studios
Isometric 3D sci-fi tower defense roguelite. Building towers, manipulating map layout and upgrading technology.
Tower DefenseReal Time TacticsRogueliteStrategyPvERTSRoguelikeOnline Co-OpSci-fiTactical👍 707
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Cell Command
Jun 19, 2025 · Alpherior
Top-down 2D sci-fi turn-based roguelite tactical RPG, colorful pixel art. Commanding cells, mixing DNA nucleotides and researching upgrades.
SingleplayerGrid-Based MovementTurn-Based TacticsTurn-Based CombatRoguelikeRogueliteTactical RPGScienceRPGTurn-Based Strategy👍 158
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Tangy TD
Mar 9 · Cakez
Top-down 2D fantasy roguelite tower defense, pixel graphics, cartoony. Placing towers, combining items and upgrading skill trees.
Tower DefenseStrategyActionSingleplayerRoguelike2DFunnyTacticalCartoonyFamily Friendly👍 1,543
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Get Outta My Gut
7 days ago · INDIE-SQUID
Top-down 2D roguelite tower defense, colorful 2D cartoon. Building turrets, defending the heart and upgrading via mutation trees.
StrategyTower DefenseRoguelikeTurn-Based TacticsActionRogueliteTurn-Based StrategySingleplayer2DBase Building
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Hexguardian
May 2, 2024 · Split Second Games
Top-down 3D fantasy tower defense roguelite strategy, cartoony, stylized. Build towers, recruit armies and defend realm.
Tower DefenseCartoonyRogueliteRoguelikeStrategyHex GridProcedural GenerationTacticalRTS3D👍 620
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Infectonator: Survivors
Aug 8, 2016 · Toge Productions
Top-down 2D post-apocalyptic roguelike survival simulation, pixel art graphics. Scavenge resources, build defenses and survive.
ZombiesStrategySurvivalIndiePixel GraphicsSimulationTower DefenseRPGActionAdventure👍 1,000
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Vitro : Bloodstream
Sep 30 · Drew VanWagner
Top-down 2D sci-fi action roguelike, luminous biology, tactile. Neutralize biological threats, collect bio energy and upgrade probe.
CasualAction RoguelikeMedical SimIncrementalPvEActionFuturisticArcade2DTop-Down
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Also worth a look

Share some of the same DNA, but further from the original.