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Games like Bio Inc. Classic

by DryGin Studios

Bio Inc. Classic is a 2D modern-day simulation strategy outbreak sim: upgrading diseases, boosting risk factors and slowing recovery. Bio Inc. Redemption and Plague Inc: Evolved play most like Bio Inc. Classic. Of the 12 closest games below, most share its outbreak sim.

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Ranked by how similar the games actually are, not by sales. Released and Price are remembered for next time.

Closest matches

Bio Inc. Redemption
Mar 8, 2018 · DryGin Studios
Both: Outbreak Sim
Same studio and core loop of managing diseases to either kill or save a patient.
Medical SimOutbreak SimSimulationStrategyManagementGoreSandboxSingleplayerMultiplayerAtmospheric👍 3,063
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Plague Inc: Evolved
Feb 18, 2016 · Ndemic Creations
Both: Outbreak Sim
Focuses on global pathogen evolution rather than individual human biology.
StrategySimulationOutbreak SimIndieSingleplayerMultiplayerZombiesCasualTacticalReplay Value👍 59,300
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Symptoms of Infection
Jun 28 · ORB Research & Broadcasting
Both: Outbreak Sim
Medical simulation where you diagnose and treat patients using realistic instrumentation.
SimulationSingleplayerOutbreak SimPsychologicalPixel GraphicsSurrealChoices MatterImmersive Sim2DMedical Sim
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Propa.
Apr 27, 2025 · ValarFerys
Both: Outbreak Sim
Microscopic warfare where you command viruses to replicate inside host cells.
StrategyRTSMinimalistPhysicsModdableMedical SimOutbreak SimNonlinearAbstractLogic
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Infectious
Aug 20, 2020 · Ziggy Makes Games
Both: Outbreak Sim
Biological combat where you mutate DNA to outsmart a host's immune system.
Outbreak SimSurvival HorrorSimulationScienceStealthRunnerRealisticAtmosphericArcadeSurvival
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Code Blue Idle
Sep 22 · Sulcus Games
Both: Idler
Medical management that scales from a single exam room to a massive hospital empire.
IdlerManagementStrategyResource ManagementSimulationMedical SimCasualIncrementalRelaxingAtmospheric
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Infectonator 3: Apocalypse
May 10, 2018 · Toge Productions
Both: Outbreak Sim
Fast-paced pathogen evolution with a focus on mutating and spreading chaos.
Outbreak SimIndieZombiesStrategySimulationSingleplayerPixel GraphicsDifficultVillain ProtagonistComedy👍 1,254
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Extinction Day
Apr 10 · DryGin Studios
Both: Outbreak Sim
God game mechanics where you deploy plagues and disasters to wipe out humanity.
Outbreak SimReal-Time with PauseSimulationGod GameResource ManagementSandboxPolitical SimManagementDystopian Destruction👍 212
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Simulator Z
Dec 15, 2023 · CASH
Both: Outbreak Sim
Sandbox simulation where you control the spread and scale of an outbreak.
SimulationSandboxOutbreak SimTop-DownZombiesSingleplayerIndieBase Building
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The Book of Plagues
Jan 16 · DiaMMax Games
Both: Outbreak Sim · Idler
Historical medical simulation where you act as a plague doctor making grim decisions.
Medical SimOutbreak SimBullet HellIdlerVisual NovelMedievalArcade2DFunnyDark Humor
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Supreme Ruler Global Outbreak
Apr 24, 2025 · BattleGoat Studios
Both: Outbreak Sim
Grand strategy approach to managing global outbreaks and national stability.
ZombiesSingleplayerSimulationStrategyOutbreak SimPost-apocalypticSurvivalGrand StrategyRTSPolitical Sim
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Zombie Cure Lab
May 27, 2025 · Thera Bytes GmbH
Both: Outbreak Sim
Lab management focused on researching an antidote to reverse a zombie infection.
Colony SimZombiesSciencePost-apocalypticResource ManagementBase BuildingOutbreak SimCity BuilderTower DefenseSandbox👍 393
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